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The neuropeptide neuromedin U promotes autoantibody-mediated arthritis
Authors:Sindhuja M Rao  Jennifer L Auger  Philippe Gaillard  Ralph Weissleder  Etsuko Wada  Richard Torres  Masayasu Kojima  Christophe Benoist  Diane Mathis  Bryce A Binstadt
Affiliation:(1) Center for Immunology and Department of Pediatrics, University of Minnesota, Medical Biosciences Building, 2101 6th St SE, Minneapolis, MN 55414, USA;(2) Department of Medicine, Division of Rheumatology, Washington University, 660 South Euclid Avenue, Campus Box 8118, St Louis, MO 63110, USA;(3) Biostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota, 717 Delaware St. SE, Minneapolis, MN 55414, USA;(4) Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Suite 5.210, Boston, MA 02114, USA;(5) Department of Degenerative Neurological Diseases, National Institute of Neuroscience, NCNP, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187, Japan;(6) Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA;(7) Department of Molecular Genetics, Institute of Life Sciences, Kurume University, 1-1 Hyakunen-kohen, Kurume, Fukuoka 839-0842, Japan;(8) Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02215, USA
Abstract:

Introduction  

Neuromedin U (NMU) is a neuropeptide with pro-inflammatory activity. The primary goal of this study was to determine if NMU promotes autoantibody-induced arthritis. Additional studies addressed the cellular source of NMU and sought to define the NMU receptor responsible for its pro-inflammatory effects.
Keywords:
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