Pigment epithelium-derived factor (PEDF) inhibits angiotensin II-induced smooth muscle cell proliferation through its anti-oxidative properties |
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| Authors: | Yamagishi Sho-ichi Matsui Takanori Nakamura Kazuo Imaizumi Tsutomu |
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| Institution: | Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Japan. shoichi@med.kurume-u.ac.jp |
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| Abstract: | Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis, suggesting that loss of this factor may be involved in angiogenic eye disease. Here, we show that PEDF inhibits angiotensin II-induced smooth muscle cell proliferation through its anti-oxidative properties. Our present study suggests that PEDF may play a protective role against atherosclerosis. |
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