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Dimethyl sulfoxide extraction of nystatin from mycelium |
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| Authors: | V V Ma?danov N L Egutkin Iu E Nikitin |
| Abstract: | Solubility of nystatin in dimethylsulfoxide (DMSO) and its water solutions was studied. It was found that the capacity of DMSO with respect to nystatin was at least 40 times higher than that of the known extracting agents. DMSO is recommended for extraction of nystatin from dry mycelium. The optimal conditions for extraction of nystatin and its recovery from the extract phases were determined. Nystatin isolated with this method meets the specification requirements. |
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