二级结构形成：蛋白质折叠起始过程的框架模型

框架模型认为二级结构形成是蛋白质起始过程的结构基础.文章介绍蛋白质同源片段的溶液构象及其构象研究法和多肽二级结构的从头设计，并综述这些研究成果应用于折叠起始过程的理论模型和蛋白质折叠起始过程的最新研究进展.

Secondary Structure Formation: Framework Model of Protein Folding Initiation

ramework model emphasizes that secondarystructure formation is the foundation of proteinfolding initiation.The paper presents the solu-tion conformation of protein fragment andmethods of conformation elucidation.and Denovo design of peptide with secondary struc-ture.Also,the application of these achieve-ments in constructing the theorftical model offolding initiation and progress on research ofprotein folding initiation up to date are detailedly reviewed.