Photoinduced DNA cleavage by benzenediradical equivalents. 1,3- and 1,4-bis(dicarbonylcyclopentadienyliron)benzene |
| |
| Authors: | Mohler Debra L Gray Coonce Janet Predecki Daniel |
| |
| Affiliation: | Department of Chemistry, Emory University, Atlanta, GA 30322, USA. dmohler@emory.edu |
| |
| Abstract: | Upon photolysis, diiron complexes 1,4- and 1,3-Fp(2)C(6)H(4) (1 and 2) linearize plasmid DNA at ratios as low as 1.5 and 3.0 molecules/bp DNA, respectively. Additionally, single-strand cleavage was observed at ratios higher than 0.05 and 0.19 molecules/bp DNA for 1 and 2, respectively. Radical scavenging studies and metal radical control experiments implicate carbon-centered radicals as participants in the cleavage pathway. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
