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Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke |
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| Authors: | Linton Steven D Aja Teresa Allegrini Peter R Deckwerth Thomas L Diaz Jose-Luis Hengerer Bastian Herrmann Julia Jahangiri Kathy G Kallen Joerg Karanewsky Donald S Meduna Steven P Nalley Kip Robinson Edward D Roggo Silvio Rovelli Giorgio Sauter Andre Sayers Robert O Schmitz Albert Smidt Robert Ternansky Robert J Tomaselli Kevin J Ullman Brett R Wiessner Christoph Wu Joe C |
| Affiliation: | Idun Pharmaceuticals, Inc., 9380 Judicial Drive, San Diego, CA 92121, USA. slinton@idun.com |
| Abstract: | Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described herein. |
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