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Antifungal activity ofBullera alba (Hanna) Derx |
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| Authors: | Wladyslav Golubev Reiko Ikeda Takako Shinoda Takashi Nakase |
| Institution: | (1) Russian Collection of Microorganisms (VKM), Institute for Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, 142292 Pushchino, Russia;(2) Department of Microbiology, Meiji College of Pharmacy, 1-22-1, Yato-cho, 188 Tanashi-shi, Tokyo, Japan;(3) The Institute of Physical and Chemical Research (RIKEN), Japan Collection of Microorganisms (JCM), 351-01 Wako-shi, Saitama, Japan |
| Abstract: | A strain ofBullera alba that secretes a killer toxin inhibitory (at pH values ranging from 3 to 7) to many ascomycetous and basidiomycetous yeast-like fungi was discovered. Its killer phenotype was incurable. The toxin was relatively thermostable and resistant to many proteases, and it was identified as a microcin. It inhibited the growth of some pathogenic yeasts and was the most active againstCryptococcus neoformans. |
| Keywords: | Bullera alba killer toxin microcin |
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