Helicobacter pylori infection generates genetic instability in gastric cells |
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| Authors: | Ana Manuel Dantas Machado,Cé u Figueiredo,Raquel Seruca,Lene Juel Rasmussen |
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| Affiliation: | 1. Department of Science, Systems and Models, University of Roskilde, Denmark;2. IPATIMUP — Institute of Molecular Pathology and Immunology of the University of Porto, Portugal;3. Medical Faculty of Porto, Portugal;4. Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark |
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| Abstract: | The discovery that Helicobacter pylori is associated with gastric cancer has led to numerous studies that investigate the mechanisms by which H. pylori induces carcinogenesis. Gastric cancer shows genetic instability both in nuclear and mitochondrial DNA, besides impairment of important DNA repair pathways. As such, this review highlights the consequences of H. pylori infection on the integrity of DNA in the host cells. By down-regulating major DNA repair pathways, H. pylori infection has the potential to generate mutations. In addition, H. pylori infection can induce direct changes on the DNA of the host, such as oxidative damage, methylation, chromosomal instability, microsatellite instability, and mutations. Interestingly, H. pylori infection generates genetic instability in nuclear and mitochondrial DNA. |
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| Keywords: | H. pylori Gastric cancer DNA repair Genetic instability |
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