Modulation of synaptic plasticity by brain estrogen in the hippocampus |
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| Authors: | Hideo Mukai Tetsuya Kimoto Yasushi Hojo Suguru Kawato Gen Murakami Shimpei Higo Yusuke Hatanaka Mari Ogiue-Ikeda |
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| Affiliation: | 1. Department of Biophysics and Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-8902, Japan;2. Core Research for Evolutional Science and Technology Project of Japan Science and Technology Agency, The University of Tokyo, Japan;3. Bioinformatics Project of Japan Science and Technology Agency, The University of Tokyo, Japan;4. Project of Special Coordinate Funds for Promoting Science and Technology, The University of Tokyo, Japan |
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| Abstract: | The hippocampus is a center for learning and memory as well as a target of Alzheimer's disease in aged humans. Synaptic modulation by estrogen is essential to understand the molecular mechanisms of estrogen replacement therapy. Because the local synthesis of estrogen occurs in the hippocampus of both sexes, in addition to the estrogen supply from the gonads, its functions are attracting much attention. |
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| Keywords: | ACSF, artificial cerebrospinal fluid AMPA, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid CNQX, 6-cyano-7-nitroquinoxaline-2,3-dione DHEA, dehydroepiandrosterone DPN, diarylpropionitrile DHT, dihydrotestosterone 17β-estradiol, E2 estrone, E1 GPR30, G protein coupled receptor 30 HSD, hydroxysteroid dehydrogenase LC-MS/MS, liquid chromatography-tandem mass spectrometry LTD, long-term depression LTP, long-term potentiation NMDA, N-methyl-d-aspartate PSD, postsynaptic density PREG, pregnenolone PPT, propyl-pyrazole-triyl)tris-phenol RIA, radioimmunoassay StAR, steroidogenic acute regulatory protein T, testosterone |
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