Mechanisms of protein kinase Sch9 regulating Bcy1 in Saccharomyces cerevisiae |
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Authors: | Zhang Aili Gao Wenxuan |
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Affiliation: | School of Biosciences, University of Birmingham, Birmingham, UK. |
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Abstract: | Because of an increased emergence of resistance to current antitubercular drugs, there is a need for new antitubercular agents directed against novel targets. Diaminopimelic acid (DAP) biosynthetic enzymes are unique to bacteria and are absent in mammals and provide a rich source of essential targets for antitubercular chemotherapy. Herein, we review the structure and function of the mycobacterial DAP biosynthetic enzymes. |
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