Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice |
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Authors: | Kumar Atul Sharma Siddharth Gupta Lalit Prakash Ahmad Pervez Srivastava Swayam Prakash Rahuja Neha Tamrakar A K Srivastava Arvind K |
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Institution: | Medicinal and Process Chemistry Division, Central Drug Research Institute, Council of Scientific and Industrial Research, Lucknow 226 001, India. dratulsax@gmail.com |
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Abstract: | A series of propiophenone derivatives (6-23) have been synthesized and evaluated for their in vivo antihyperglycemic activities in sucrose loaded model (SLM), sucrose challenged streptozotocin (STZ-S) induced diabetic rat model and C57BL/KsJ db/db diabetic mice model. Compound 15 and 16 were emerged as potent antihyperglycemics and lipid lowering agents. These compounds (15, 16) further validate the potency by reducing body weight and food intake in db/db mice model. Possible mechanism of action for the propiophenone derivatives was established by the evaluation in various in vitro models. Interestingly some of the compounds were efficiently inhibiting PTP-1B. |
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