Synthesis and biological evaluation of 7-azaindole derivatives, synthetic cytokinin analogues |
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Authors: | Guillard Jérome Decrop Maÿlis Gallay Nathalie Espanel Claire Boissier Elodie Herault Olivier Viaud-Massuard Marie-Claude |
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Affiliation: | SPOT-EA3857, UFR des Sciences Pharmaceutiques, 31 Avenue Monge, 37200 Tours, France. |
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Abstract: | Cytokinins, N6-substituted adenine derivatives, are plant hormones playing important roles in various processes in plant development. Furthermore, cytokinins and their derivatives are able to control mammalian cell apoptosis and differentiation. The aim of our study was the synthesis of 7-azaindole derivatives as cytokinin analogues with the Hartwig-Buchwald coupling reaction in order to evaluate their biological properties on human myeloblastic leukaemia cells (HL-60 cell line). All these compounds presented a cytotoxic activity on HL-60 cells especially the 4-phenylaminopyrrolo[2,3-b]pyridine and the 4-phenethylaminopyrrolo[2,3-b]pyridine. |
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