On the complexity of fundamental computational problems in pedigree analysis. |
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Authors: | Antonio Piccolboni Dan Gusfield |
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Affiliation: | Computer Science Department, University of California, Davis 95616, USA. antonio-piccolboni@affymetrix.com |
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Abstract: | Pedigree analysis is a central component of many current efforts to locate genes that contribute to diseases or to valuable traits. The analysis usually involves solving one of two very computation-intense problems. We analyze the complexity of these two problems. Surprisingly, we show that both problems are NP-hard even for pedigrees that contain no inbreeding loops. |
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