Validation of numerical flow simulations against in vitro phantom measurements in different type B aortic dissection scenarios |
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Authors: | Eduardo Soudah Paula Rudenick Maurizio Bordone Bart Bijnens David García-Dorado Arturo Evangelista |
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Affiliation: | 1. Department of Biomedical Engineering, International Center for Numerical Methods in Engineering (CIMNE), Universitat Politècnica de Catalunya, Barcelona, Spainesoudah@cimne.upc.edu;3. University Hospital and Research Institute Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain;4. Department of Biomedical Engineering, International Center for Numerical Methods in Engineering (CIMNE), Universitat Politècnica de Catalunya, Barcelona, Spain;5. ICREA, PhySense – N-RAS, Universitat Pompeu Fabra, Barcelona, Spain |
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Abstract: | An aortic dissection (AD) is a serious condition defined by the splitting of the arterial wall, thus generating a secondary lumen [the false lumen (FL)]. Its management, treatment and follow-up are clinical challenges due to the progressive aortic dilatation and potentially severe complications during follow-up. It is well known that the direction and rate of dilatation of the artery wall depend on haemodynamic parameters such as the local velocity profiles, intra-luminal pressures and resultant wall stresses. These factors act on the FL and true lumen, triggering remodelling and clinical worsening. In this study, we aimed to validate a computational fluid dynamic (CFD) tool for the haemodynamic characterisation of chronic (type B) ADs. We validated the numerical results, for several dissection geometries, with experimental data obtained from a previous in vitro study performed on idealised dissected physical models. We found a good correlation between CFD simulations and experimental measurements as long as the tear size was large enough so that the effect of the wall compliance was negligible. |
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Keywords: | aortic dissection computational fluid dynamics in vitro phantoms aortic diseases |
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