Differences between peritoneal and pleural mesothelioma in Lombardy,Italy |
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| Affiliation: | 1. Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico, Milan, Italy;2. School of Occupational Medicine, Università degli Studi di Milano, Milan, Italy;3. Abadan School of Medical Sciences, Abadan, Iran;1. Department of Pediatrics, Chung-Ang University Hospital, Seoul, Republic of Korea;2. Department of Internal Medicine, Nasaret International Hospital, Incheon, Republic of Korea;3. Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;4. College of Medicine, Chung-Ang University, Seoul, Republic of Korea;5. Department of Pediatrics, Asan Medical Center, Children’s Hospital, University of Ulsan College of Medicine, Seoul, Republic of Korea;1. Collaboration for Cancer Outcomes, Research and Evaluation, The Ingham Institute for Applied Medical Research, Liverpool Hospital, UNSW, Sydney, Australia;2. Applied Radiation Biology and Radiotherapy Section, Division of Human Health e Department of Nuclear Sciences and Applications, International Atomic Energy Agency, PO Box 100, 1400 Vienna, Austria;1. Biomedical Research Foundation, House # 7, Apartment # 1A, Road # 1/B, Chairman Bari, Banani, Dhaka 1213, Bangladesh;2. Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chittagong 4331, Bangladesh;3. School of Environmental Science and Management, Independent University, Bangladesh;1. Service de Gynécologie-Obstétrique Centre Hospitalier Universitaire de Guadeloupe, Guadeloupe F.W.I. Route de Chauvel, 97159 Pointe-à-Pitre Cedex, France;2. Institut National de la Santé et de la Recherche Médicale Inserm U1085–IRSET, Campus Universitaire de Fouillole, Pointe à Pitre 97157, Guadeloupe, France;3. Service d’Anatomopathologie, Centre Hospitalier Universitaire de Guadeloupe, Guadeloupe F.W. I. Route de Chauvel, 97159 Pointe-à-Pitre Cedex, France;4. Registre Général des Cancers de Guadeloupe, Centre Hospitalier Universitaire de Guadeloupe, Guadeloupe F.W. I. Route de Chauvel, 97159 Pointe-à-Pitre Cedex, France;1. Department of Family Medicine and Community Health, JABSOM – University of Hawaii at Manoa, 677 Ala Moana Blvd, Suite 815, Honolulu, HI 96813, United States;2. Yap State Department of Health Services, P.O. Box 1010, Colonia, Yap 96943, Federated States of Micronesia;1. Department of Oncology, Queen’s University, Kingston, Canada;2. Department of Surgery, Queen’s University, Kingston, Canada;3. Division of Cancer Care and Epidemiology, Queen’s University Cancer Research Institute, Canada |
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| Abstract: | BackgroundWe examined characteristics of peritoneal (PEM) and pleural (PLM) mesothelioma in Lombardy, Italy.MethodsFrom the Lombardy Mesothelioma Registry we selected PEM (N = 300) and PLM (N = 5011) cases diagnosed in 2000–2014. We investigated asbestos exposure and presence of asbestosis or pleural plaques.ResultsIncidence rates (per 1,000,000 person-years, world standardized) of PEM were 1.2 (men) and 0.9 (women), compared with 22.6 and 8.4 for PLM.Asbestosis (both genders) and pleural plaques (men) were more frequent among PEM cases. Occupational asbestos exposure was similar in PEM and PLM cases. We found higher proportions of PEMs employed in the asbestos cement production.ConclusionThe higher frequency of pleural plaques in PEM cases confirm the association between asbestos and peritoneal mesothelioma. The higher proportions of asbestosis and of past employment in the asbestos-cement sector among PEM cases suggest a possible role of high exposures to asbestos in the peritoneal mesothelioma genesis. |
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| Keywords: | Asbestos Mesothelioma Peritoneum Population-based registry |
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