Stage IV colorectal cancer primary site and patterns of distant metastasis |
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| Institution: | 1. Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle WA, 98109, USA;2. Department of Epidemiology, University of Washington, 1959 NE Pacific St., Health Sciences Building, F-262, Seattle, WA, 98195, USA;3. Department of Medicine, University of Washington, 1959 NE Pacific St., Health Sciences Building, RR-512, Seattle, WA, 98195, USA;1. Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, United States;2. University of Illinois at Chicago Cancer Center, Cancer Control and Population Science Research Program, Chicago, United States;3. Institute for Health Research and Policy, Chicago, United States;4. Department of Otolaryngology-Head and Neck Surgery, University of Illinois at Chicago, Chicago, United States;5. School of Public Health, University of Alberta, Edmonton, Alberta, Canada;6. University of Illinois at Chicago, Department of Pediatrics, Chicago, United States;7. Survey Research Laboratory, Public Administration, University of Illinois at Chicago, 412 South Peoria Street, Chicago, 60607, United States;8. University of Illinois at Chicago, Department of Medicine, Chicago, United States;9. Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, United States;1. Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom;2. School of Pharmacy, Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom;3. Centre of Excellence for Public Health (NI), Centre for Public Health, Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom;1. EPIUnit ? Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, no 135, 4050-600 Porto, Portugal;2. Registo Oncológico Regional do Norte (RORENO) ? Instituto Português de Oncologia do Porto, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal;3. Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal;1. Dept of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Yoshidakonoecho, Sakyoku, Kyoto 606-8501, Japan;2. Dept of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia;3. Dept of Surgery, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia;4. Dept of Clinical Oncology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia;5. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P.O. Box 85500, 3508 GA, Utrecht, Netherlands;1. Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research Unioninkatu 22, 00130 Helsinki, Finland;2. University of Helsinki, Department of Public Health, PO Box 41 (Mannerheimintie 172), FI-00014 University of Helsinki, Finland;3. Faculty of Social Sciences, University of Tampere, FI-33014 University of Tampere, Finland |
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| Abstract: | BackgroundAlthough colorectal cancer (CRC) usually metastasizes to the liver and/or lungs, factors influencing the anatomic pattern of metastases remain poorly understood.MethodsWe assessed the relationship between primary CRC site and pattern of synchronous metastasis among 1202 individuals diagnosed with incident metastatic CRC between 2010 and 2014 and identified through the Seattle-Puget Sound Surveillance, Epidemiology, and End Results (SEER) registry. Polytomous logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between primary tumor site and synchronous metastatic pattern.ResultsCompared to patients with proximal colon primaries, patients with rectal primaries were more likely to present with lungs-only or liver and lungs metastases versus liver-only metastases (ORlungs–onlyvs.liver-only: 2.39, 95% CI: 1.35–4.24, ORliver+lungsvs.liver-only: 2.20, 95% CI: 1.46–3.32).ConclusionThese findings suggest that patients with rectal primaries are more likely than patients with colon primaries to present with synchronous lung metastases. |
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| Keywords: | Colorectal neoplasms Colonic neoplasms Rectal neoplasms Neoplasm metastasis Population-based cancer registry Epidemiology |
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