Sedentary work and the risks of colon and rectal cancer by anatomical sub-site in the Canadian census health and environment cohort (CanCHEC) |
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| Institution: | 1. Occupational Cancer Research Centre, Cancer Care Ontario, 525 University Avenue, Toronto, Ontario M5G 2L3, Canada;2. School of Occupational and Public Health, Ryerson University, 350 Victoria Street, POD 249, Toronto, Ontario M5B 2K3, Canada;3. Dalla Lana School of Public Health, University of Toronto, 155 College Street, 6th Floor, Toronto, Ontario M5T 3M7, Canada;4. Health Analysis Division, Statistics Canada, 150 Tunney''s Pasture Driveway, Ottawa, Ontario K1A 0T6, Canada;5. Departments of Sociology and Economics, University of New Brunswick Fredericton Campus, P.O. Box 4400, Fredericton, New Brunswick E3B 5A3, Canada;6. CAREX Canada, Faculty of Health Sciences, Blusson Hall 11300, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada;1. Cancer Control and Population Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, United States;2. Department of Pediatrics, Division of Pediatric Hematology/Oncology, University of Utah School of Medicine, Salt Lake City, UT 84113, United States;3. Department of Institutional Research and Reporting, Salt Lake Community College, Salt Lake City, UT 84123, United States;4. Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555, United States;5. Department of Pediatric Hematology/Oncology, Salt Lake City Primary Children’s Hospital, UT 84132, United States;6. Division of Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84132, United States;1. Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, United States;2. Harvard Medical School, Boston, MA, United States;3. Kaiser Permanente Colorado, Institute for Health Research, Denver, CO, United States;4. Kaiser Permanente Center for Health Research, Portland, OR, United States;5. School of Public Health, University of Washington, Seattle, WA, United States;1. EPIUnit ? Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, no 135, 4050-600 Porto, Portugal;2. Registo Oncológico Regional do Norte (RORENO) ? Instituto Português de Oncologia do Porto, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal;3. Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro, 4200-319 Porto, Portugal;1. Research Unit for General Practice, Department of Public Health, Aarhus University, Bartholins Allé 2, 8000 Aarhus C, Denmark;2. Research Centre for Cancer Diagnosis in Primary Care, Department of Public Health, Aarhus University, Bartholins Allé 2, 8000 Aarhus C, Denmark;3. Diagnostic Centre, University Research Clinic for Innovative Patient Pathways, Silkeborg Regional Hospital, Falkevej 1-3, 8600 Silkeborg, Denmark;4. Cancer Epidemiology and Population Health, King’s College London, Great Maze Pond, London SE1 9RT, United Kingdom;1. Department of Otolaryngology-Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, 650-8507, Japan;2. Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, 650-8501, Japan;1. Department of Epidemiology and Health Statistics, School of Public Health, Zhejiang University, Hangzhou, China;2. Group of Molecular Epidemiology & Cancer Precision Prevention (GMECPP), Institute of Occupational Diseases, Zhejiang Academy of Medical Sciences (ZJAMS), Hangzhou, China;3. Xiamen Second Hospital, Xiamen, China;4. Jiashan Institute of Cancer Prevention and Treatment, Zhejiang Province, China |
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| Abstract: | BackgroundSedentary behaviour is a potential risk factor for colorectal cancer. We examined the association between sedentary work, based on body position, and colorectal cancer risk in Canadians.MethodsA working body position category (a. sitting; b. standing and walking; c. sitting, standing, and walking; d. other) was assigned to occupations reported by 1991 Canadian Census respondents based on national occupational counselling guidelines. Adjusted hazard ratios (HRs) and 95% confidence intervals (CI) were estimated for cancers of the colon (overall, proximal, and distal) and rectum in men and women newly diagnosed from 1992 to 2010.ResultsCompared to “sitting” jobs, men in occupations with “other” (non-sitting, ?standing, or ?walking) body positions had a weakly significant reduced colon cancer risk (HR = 0.93, 95% CI: 0.89, 0.98) primarily attributed to protection at the distal site (HR = 0.90, 95% CI: 0.84, 0.97). Men in “standing and walking” and “sitting, standing, and walking” jobs did not have significantly reduced colon cancer risks. No effects were observed for rectal cancer in men or colon and rectal cancer in women.ConclusionThe two significant findings of this analysis should be followed-up in further investigations with additional information on potential confounders. Null findings for rectal cancer were consistent with other studies. |
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| Keywords: | (MeSH): Cohort study Occupation Colon cancer Rectal cancer Sedentary lifestyle |
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