首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Association of maternal and index child’s diet with subsequent leukemia risk: A systematic review and meta analysis
Institution:1. Department of Neurology, The People''s Hospital of Yichun City, Yichun University, 1061 Jinxiu Road, Yichun, Jiangxi Province, 336000, PR China;2. Department of Neurology, The Fifth Central Hospital of Tianjin, Binhai Hospital of Peking University, 40 Zhe Jiang Road of Binhai New Area, Tianjin, 300450, PR China;3. Department of Neurology, The First People''s Hospital of Taizhou City, The Affiliated Huangyan Hospital of Wenzhou Medical University, 218 Hengjie Road, Taizhou, Zhejiang Province, 318020, PR China;4. Department of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, 250 East Changgang Road, Guangzhou, Guangdong Province, 510260, PR China;5. Departments of Neuroscience and Behavioral Medicine & Psychiatry, the Rockefeller Neurosciences Institute, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA;6. Department of Histology and Embryology, Yichun University, Xuefu Road, Yichun, Jiangxi Province, 336000, PR China
Abstract:BackgroundExploring the effect of maternal and/or childhood diet on offspring leukemogenesis is challenging, given differences in food group categories, their potentially variable impact depending on time window of exposure and the multiple leukemia subtypes. We opted to quantitatively synthesize published data on the association of maternal/child diet with leukemia risk.MethodsMedline was searched until June 30th, 2016 for eligible articles on the association of childhood leukemia with consumption of (i) food groups, excluding alcoholic and non-alcoholic beverages, and (ii) specific dietary supplements before/during index pregnancy and childhood.ResultsEighteen studies of case-control design (N = 11,720 cases/18,721 controls) were included, of which nine assessed maternal dietary components, five index child’s and four both, mainly focusing on acute lymphoblastic leukemia (ALL). Statistically significant inverse estimates for ALL were found (2 studies, 413 cases, 490 controls) for fruit (OR: 0.81, 95% CI: 0.67, 0.99); vegetables (OR: 0.51, 95% CI: 0.28, 0.94); legumes (OR: 0.76, 95% CI: 0.62, 0.94); fish (OR: 0.27, 95% CI: 0.14, 0.53, among the 0–4 year old; 2 studies 215 cases, 215 controls); preconception folic acid supplementation (OR: 0.69, 95%CI: 0.50–0.95; published meta analysis plus 2 studies, 3511 cases, 6816 controls); and use of vitamins during pregnancy (OR: 0.81, 95%CI: 0.74–0.88; published meta analysis plus one study, 5967 cases, 8876 controls). The associations (2 studies) of the remaining food groups and maternal dietary supplements consumption during pregnancy as well as of childhood diet and supplements intake (2–4 studies) were non significant.ConclusionsMaternal consumption of specific food groups comprising“healthy” items of the Mediterranean diet, preconception use of folic acid and intake of vitamins during pregnancy were associated with decreased ALL risk. Further research is needed, however preferably with homogeneous dietary information and data on immunophenotypic/cytogenetic subtypes to also explore the interaction of specific macro- and micronutrients intake with gene polymorphisms.
Keywords:Preconception  Maternal diet  Childhood diet  Food group  Micronutrients  Supplements  Folic acid  Iron  Vitamins  Leukemia
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号