Alcohol consumption and risk of upper-tract urothelial cancer |
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| Affiliation: | 1. Department of Public Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan;2. Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, 7th floor, Boston, MA, 02115 USA;3. Department of Urology, Kanto Rosai Hospital, 1-1 Kizukisumiyoshi-cho, Nakahara-ku, Kawasaki, Kanagawa, 211-8510, Japan;1. Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom;2. School of Pharmacy, Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom;3. Centre of Excellence for Public Health (NI), Centre for Public Health, Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom;1. Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Denmark;2. Division of Dermatology, University of Louisville, Louisville, KY, USA;3. Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Denmark;1. University College London, UK;2. London School of Hygiene and Tropical Medicine, UK;3. MRC Clinical Trials Unit at UCL, London, UK;1. Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, United States;2. University of Illinois at Chicago Cancer Center, Cancer Control and Population Science Research Program, Chicago, United States;3. Institute for Health Research and Policy, Chicago, United States;4. Department of Otolaryngology-Head and Neck Surgery, University of Illinois at Chicago, Chicago, United States;5. School of Public Health, University of Alberta, Edmonton, Alberta, Canada;6. University of Illinois at Chicago, Department of Pediatrics, Chicago, United States;7. Survey Research Laboratory, Public Administration, University of Illinois at Chicago, 412 South Peoria Street, Chicago, 60607, United States;8. University of Illinois at Chicago, Department of Medicine, Chicago, United States;9. Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, United States;1. Registre des cancers du Bas-Rhin, Laboratoire d’Épidémiologie et de Santé Publique, EA3430, FMTS, Université de Strasbourg, 4 rue Kirschleger, 67085 Strasbourg CEDEX, France;2. Service de Santé Publique, Hôpitaux Universitaires de Strasbourg, 1 place de l’hôpital, 67091 Strasbourg CEDEX, France;3. Service d’épidémiologie et de biostatistique, Centre Paul Strauss, 3 rue de la porte de l’hôpital, 67065 Strasbourg CEDEX, France;4. Registre des tumeurs de l''Hérault, Centre de Recherche, 208 rue des Apothicaires, 34298 Montpellier CEDEX 5, France;5. Registre des cancers de la Manche, Centre Hospitalier Public du Cotentin, 46 rue du Val de Saire, 50102 Cherbourg-Octeville, France;6. Registre des cancers du Tarn, 1, rue Lavazière BP 37, 81001 Albi CEDEX, France;7. Institut Claudius Regaud, IUCT-O, LEASP – UMR 1027 Inserm – Université Toulouse III, 1 avenue Irène Joliot-Curie, 31059 Toulouse CEDEX 9, France;8. Registre du cancer de la Somme, Service Épidémiologie, Hygiène et Santé Publique, Centre Hospitalier Universitaire Nord, 1 place Victor Pauchet, 80054 Amiens CEDEX 1, France;9. Registre des hémopathies malignes de Basse-Normandie, Unité Fonctionnelle Hospitalo- Universitaire n°0350, Centre Hospitalier Universitaire Nord, avenue de la Côte de Nacre, 14033 Caen CEDEX, France;10. Registre des cancers de Loire-Atlantique et Vendée, Centre Hospitalier Universitaire de Nantes, 50 route de Saint-Sébastien, 44093 Nantes CEDEX 1, France;11. Registre général des cancers de Lille et de sa région, GCS C2RC, Centre Hospitalier Régional Universitaire de Lille Hôpital Calmette, boulevard du Professeur Jules Leclercq, 59037 Lille CEDEX, France;12. Registre des tumeurs du Doubs et du Territoire de Belfort − EA3181, Centre Hospitalier Régional Universitaire de Besançon Saint-Jacques, 2 place Saint-Jacques, 25030 Besançon CEDEX, France;13. Registre des tumeurs digestives du Calvados, Cancers & Préventions – U 1086 Inserm, Centre François Baclesse, 3 avenue du Général Harris, BP 5026 14076 Caen CEDEX 5, France;14. Registre des cancers de l’Isère, Centre Hospitalier Universitaire de Grenoble Pavillon E, boulevard de la Chantourne BP 217, 38043 Grenoble CEDEX 9, France;15. Registre général des tumeurs du Calvados, Cancers & Préventions – U 1086 Inserm, Centre François Baclesse, 3 avenue du Général Harris, BP 5026 14076 Caen CEDEX 5, France;p. Francim: Réseau français des registres des cancers, 31073 Toulouse, France;1. Wardliparingga Aboriginal Research Unit, South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA, 5000, Australia;2. Centre for Population Health Research, School of Health Sciences, Sansom Institute for Health Research, University of South Australia, North Terrace, Adelaide, SA, 5000, Australia;3. Transforming Health, SA Health, Hindmarsh Square, Adelaide, SA, 5000, Australia;4. Faculty of Health Sciences, University of Adelaide, North Terrace, Adelaide, SA, 5000, Australia;5. School of Nursing and Midwifery, University of South Australia, North Terrace, Adelaide, SA, 5000, Australia;6. Aboriginal Health Research Group, Sansom Institute for Health Research, University of South Australia, North Terrace, Adelaide, SA, 5000, Australia |
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| Abstract: | BackgroundUpper-tract urothelial cancer (UTUC), which includes renal pelvic cancer and ureter cancer, is a rare cancer and its prognosis is poor. Smoking and high-risk occupations (e.g., printing and dyestuff working which involves exposure to aniline dyes) are well-known risk factors for UTUC. However, the risk of alcohol consumption in UTUC remains unclear. This study aimed to determine whether alcohol consumption is an independent risk factor for UTUC.MethodsThe study was a case–control study which used the nationwide clinical inpatient database of the Rosai Hospital group in Japan. We identified 1569 cases and 506,797 controls between 1984 and 2014. We estimated the odds ratio (OR) and 95% confidence interval (95%CI) of alcohol consumption for UTUC – never, up to 15 g/day, >15–30 g/day, or >30 g/day – using unconditional logistic regression. We adjusted for the following covariates: age, sex, study period, hospital, history of smoking, and high-risk occupation.ResultsThe risk of UTUC was significantly higher in ever-drinkers compared with never-drinkers (OR = 1.23, 95%CI, 1.08–1.40; P = 0.001). Compared with never-drinkers, the risk threshold for UTUC was >15 g of alcohol consumption per day (equivalent to 6 ounces of Japanese sake containing 23 g of alcohol). A dose-response was observed (P < 0.001).ConclusionAlcohol consumption may be an independent risk factor for UTUC, with a low-risk threshold of 15 g of alcohol per day. |
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| Keywords: | Alcohol consumption Case–control study Dose-response Japanese Occupation Renal pelvis Smoking Splines Upper tract urothelial cancer Ureter |
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