Coffee and tea consumption and risk of leukaemia in an adult population: A reanalysis of the Italian multicentre case-control study |
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| Institution: | 1. Institute of Electronics, Computer and Telecommunication Engineering, National Research Council of Italy, Genoa, Italy;2. Unit of Clinical Trials, IRCCS San Martino-IST, Genoa, Italy;3. Liguria Mortality Registry, IRCCS AOU San Martino-IST National Cancer Research Institute, Largo Rosanna Benzi, 10, 16132 Genoa, Italy;4. Unit of Clinical Epidemiology, IRCCS AOU San Martino-IST National Cancer Research Institute, Largo Rosanna Benzi, 10, 16132, Genoa, Italy;1. Registre général des Cancers de Guadeloupe, Centre Hospitalier Universitaire de Guadeloupe, Guadeloupe;2. Service d’anatomopathologie, Centre Hospitalier Universitaire de Guadeloupe, Guadeloupe;3. Service d’Oncologie-Radiothérapie, Centre Hospitalier Universitaire de Guadeloupe, Guadeloupe;4. Service de Gynécologie-Obstétrique, Centre Hospitalier de la Basse-Terre, Guadeloupe;5. Service de Gynécologie-Obstétrique, Centre Hospitalier Universitaire de Guadeloupe, Guadeloupe;6. Institut National de la Santé et de la Recherche Médicale Inserm U1085 - IRSET, Campus Universitaire de Fouillole, Guadeloupe;1. Department of Oral and Maxillofacial Surgery, Changhua Christian Hospital, 135, Nan-Hsiao Street, Changhua 500, Taiwan;2. Department of Internal Medicine, Changhua Christian Hospital, 135, Nan-Hsiao Street, Changhua 500, Taiwan;3. Green Energy and Environment Research Laboratories, Industrial Technology Research Institute, No. 195, Section 4, Chung Hsing Road, Chutung, Hsinchu 310, Taiwan;4. Graduate Institute of Statistics and Information Science, National Changhua University of Education, Changhua 500, Taiwan;1. Cancer Epidemiology and Health Services Research Group, Centre for Public Health, Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom;2. School of Pharmacy, Queen’s University Belfast, Northern Ireland, United Kingdom;3. Centre of Excellence for Public Health (NI), Centre for Public Health, Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom;1. Primary Care Research Unit of Mallorca, Baleares Health Services-IbSalut, 07005 Palma, España, Instituto de Investigación Sanitaria de Palma, 07010 Palma, Spain;2. Evaluation and Clinical Epidemiology Department, Hospital del Mar, Passeig Marítim 25-29, 08003, Barcelona, Spain;3. Clinical Epidemiology and Biostatistics Unit, A Coruña University, Complexo Hospitalario Universitario A Coruña, Xubias de Arriba, 84, Hotel de los pacientes 7ª planta, 15006, A Coruña, Spain;4. Serreria II Primary Care Centre, Valencia Institute of Health, C/Pedro de Valencia 28, 46022, Valencia, Spain;5. Canal Imperial Primary Care Centre, Paseo Colon 4, Zaragoza, 50006, Spain;6. Department of Public Health, Balearic Department of Health, C/Jesus n 33, 07001, Instituto de Investigación Sanitaria de Palma, 07010 Palma, Spain, Spain;1. University of Tampere, School of Health Sciences, Tampere, Finland;2. Department of Clinical Chemistry, Helsinki University Central Hospital, Finland;3. Tampere University Hospital, Department of Urology and University of Tampere, Medical School, Tampere, Finland;4. Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands;5. Sahlgrenska Academy at Göteborg University, Gothenburg, Sweden;6. Memorial Sloan-Kettering Cancer Centre, Department of Surgery and Department of Epidemiology and Biostatistics, New York, NY, USA;7. Finnish Cancer Registry, Helsinki, Finland;1. Cancer Prevention Institute of California, Fremont, CA, United States;2. Department of Health Research and Policy (Epidemiology), Stanford University School of Medicine, Stanford, CA, United States;3. Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis School of Medicine, Sacramento, CA, United States |
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| Abstract: | BackgroundCoffee and tea are the most frequently consumed beverages in the world. Their potential effect on the risk of developing different types of malignancies has been largely investigated, but studies on leukaemia in adults are scarce.MethodsThe present investigation is aimed at evaluating the potential role of regular coffee and tea intake on the risk of adult leukaemia by reanalysing a large population based case-control study carried out in Italy, a country with a high coffee consumption and a low use of green tea. Interviewed subjects, recruited between 1990 and 1993 in 11 Italian areas, included 1771 controls and 651 leukaemia cases. Association between Acute Myeloid Leukaemia (AML), Acute Lymphoid Leukaemia, Chronic Myeloid Leukaemia, Chronic Lymphoid Leukaemia, and use of coffee and tea was evaluated by standard logistic regression. Odds Ratios (OR) were estimated adjusting for the following potential confounders: gender, age, residence area, smoking habit, educational level, previous chemotherapy treatment, alcohol consumption and exposure to electromagnetic fields, radiation, pesticides and aromatic hydrocarbons.ResultsNo association was observed between regular use of coffee and any type of leukaemia. A small protective effect of tea intake was found among myeloid malignancies, which was more evident among AML (OR = 0.68, 95%CI: 0.49–0.94). However, no clear dose-response relation was found.ConclusionThe lower risk of leukaemia among regular coffee consumers, reported by a few of previous small studies, was not confirmed. The protective effect of tea on the AML risk is only partly consistent with results from other investigations. |
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| Keywords: | Adult leukaemia Lymphoid malignancies Myeloid malignancies Tea Coffee Case-control study |
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