| 精卵细胞融合分子机制 |
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| 引用本文： | 郭晓强,杨彩卿. 精卵细胞融合分子机制[J]. 细胞生物学杂志, 2007, 29(3): 361-364 |
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| 作者姓名： | 郭晓强 杨彩卿 |
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| 作者单位： | 解放军白求恩军医学院生物化学教研室 石家庄050081(郭晓强)，保定师范专科学校定州分校 定州073000(杨彩卿) |
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| 摘 要： | 精卵融合是有性生殖中最为关键的事件之一,因此对该过程分子机制的理解具有十分重要意义。已经发现多种蛋白质涉及到这个重要的过程,主要包括卵子表面的CD9、GPI锚定蛋白和整合素等,精子表面的附睾蛋白DE、Izumo和ADAM家族成员等,它们通过特异性的识别和结合而辅助完成了精卵融合。这些进展对开发新的用于生殖调节或不育诊断和治疗技术、药物提供了保证。
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| 关 键 词： | 精子 卵子 融合 |
| 修稿时间： | 2006-05-082006-12-28 |
Molecules Mechanism of Sperm-oocyte Fusion |
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| Xiao-Qiang Guo,Cai-Qing Yang. Molecules Mechanism of Sperm-oocyte Fusion[J]. Chinese Journal of Cell Biology, 2007, 29(3): 361-364 |
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| Authors: | Xiao-Qiang Guo Cai-Qing Yang |
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| Affiliation: | Department of Biochemistry, Bethune Military Medical College, Shijiazhuang 050081, China; 1Department of Dingzhou, Baoding Normal College, Dingzhou 073000, China |
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| Abstract: | Sperm-oocyte fusion is one of the most key events in sexual reproduction, so it has an important significance to understand its molecular mechanism. There are several molecules that involved in sperm-oocyte fusion, such as CD9, glycosylphosphatidylinositol-anchored proteins and integrins on oocytes, and epididymal pro-tein DE, Izumo and ADAMs on sperm. These molecules assist to complete sperm-egg fusion by special recognition and binding. These progress has vital application in developing new methods for both fertility regulation and diagno-sis and treatment of human infertility. |
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| Keywords: | sperm oocyte fusion |
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