Two useful dimensionless parameters that combine physiological, operational and bioreactor design parameters for improved control of dissolved oxygen |
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| Authors: | A. De León A.P. Barba-de la Rosa H. Mayani E. Galindo O.T. Ramírez |
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| Affiliation: | (1) Depto. de Ingeniería Bioquímica, Av. Tecnológico y García Cubas s/n, Instituto Tecnológico de Celaya, Celaya, Gto., A.P, 57, C.P. 38010, México;(2) Hospital de Oncología, Centro Médico Nacional Siglo XXI, México, D.F., México;(3) Instituto de Biotecnología, Depto. de Bioingeniería, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, 62250, México |
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| Abstract: | Two new dimensionless parameters ( and  ) are proposed for calculating the proportional, integral, and derivative constants of a dissolved oxygen proportional integral-derivative (PID) feed-back control algorithm from knowledge of the growth rate, bioreactor design and operation variables. The values of and were determined for a broad range of Reynolds numbers (between 1000 to 40 000) during the exponential growth phase of two highly different processes: fermentations of recombinant Escherichia coli and cultures of human hematopoietic cells. The utility of and for use in dissolved oxygen self-tunning adaptive control algorithms is discussed. |
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| Keywords: | bioreactor dimensionless numbers dissolved oxygen hematopoietic cells PID controller recombinant E. coli |
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