| Wnt信号在胚胎干细胞自我更新和分化中的作用 |
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| 引用本文： | 叶守东,谭理,宋后燕,李平. Wnt信号在胚胎干细胞自我更新和分化中的作用[J]. 生命科学, 2010, 0(2): 129-132 |
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| 作者姓名： | 叶守东 谭理 宋后燕 李平 |
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| 作者单位： | 复旦大学分子医学教育部重点实验室; |
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| 基金项目： | 上海市自然科学基金(09ZR1404000) |
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| 摘 要： | 胚胎干细胞分离自胚泡内细胞团,具有无限自我更新和多向分化潜能,有很大的医学应用前景。Wnt家族是一类分泌型的细胞信号传导蛋白,可以通过复杂的信号传递通路调控胚胎的早期发育,对细胞的分化、增殖及生长具有重要的调节作用。该文就Wnt信号通路调节胚胎干细胞的自我更新和分化作一综述。
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| 关 键 词： | Wnt信号通路 自我更新 分化 |
Role of Wnt signalling in the self-renewal and differentiation of embryonic stem cells |
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| YE Shou-dong,TAN Li,SONG Hou-yan,LI Ping. Role of Wnt signalling in the self-renewal and differentiation of embryonic stem cells[J]. Chinese Bulletin of Life Sciences, 2010, 0(2): 129-132 |
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| Authors: | YE Shou-dong TAN Li SONG Hou-yan LI Ping |
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| Affiliation: | YE Shou-dong,TAN Li,SONG Hou-yan,LI Ping(The Key Laboratory of Molecular Medicine,Ministry of Education,Shanghai Medical College,Fudan University,Shanghai 20032,China) |
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| Abstract: | Embryonic stem cells,derived from the inner cell mass of blastocysts,hold significant potential for clinical therapies because of their distinctive capacity to both self-renew and differentiate into a wide range of specialized cell types.Wnts comprise a large family of secreted glycoproteins that regulate a variety of develop-mental changes,including cellular proliferation,differentiation and migration.Here,we will review the impor-tance of the Wnt signalling pathway in regulating the self-renewal and diffe... |
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| Keywords: | Wnt self-renew differentiation |
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