In Vitro Antifungal Activity of Dihydroxyacetone Against Causative Agents of Dermatomycosis |
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Authors: | Cheila Denise Ottonelli Stopiglia Fabiane Jamono Vieira Andressa Grazziotin Mondadori Tércio Paschke Oppe Maria Lúcia Scroferneker |
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Institution: | 1.Graduate Program in Medicine, Medical Sciences,Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil;2.Laboratory of Pathogenic Fungi, Department of Microbiology, Institute of Basic Health Sciences,Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil;3.School of Pharmacy,Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil;4.Instituto de Ciências Básicas da Saúde,Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil |
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Abstract: | Dihydroxyacetone (DHA), a three-carbon sugar, is the browning ingredient in commercial sunless tanning formulations. DHA preparations
have been used for more than 50 years and are currently highly popular for producing temporary pigmentation resembling an
ultraviolet-induced tan. In this work, the in vitro antifungal activity of dihydroxyacetone was tested against causative agents
of dermatomycosis, more specifically against dermatophytes and Candida spp. The antifungal activity was determined by the broth microdilution method according to the Clinical and Laboratory Standards Institute guidelines for yeasts and filamentous fungi. The data obtained show that the fungicidal activity varied from 1.6 to 50 mg ml−1. DHA seems to be a promising substance for the treatment of dermatomycosis because it has antifungal properties at the same
concentration used in artificial suntan lotions. Therefore, it is a potential low-toxicity antifungal agent that may be used
topically because of its penetration into the corneal layers of the skin. |
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