Radiation-induced cell cycle arrests in Ehrlich ascites carcinoma cells in vivo |
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| Authors: | S. V. Tokalov A. S. Iagunov |
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| Affiliation: | 1.Medical Faculty Carl Gustav Carus,OncoRay—Center for Radiation Research in Oncology, Dresden University of Technology,Dresden,Germany;2.Research Laboratory of the Late Radiation Pathology,The Russian Center for Research in Radiological and Surgical Techniques,St. Petersburg,Russia |
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| Abstract: | Radiation-induced progression delay in G1/S, S and G2/M phases of p53 wild-type Ehrlich ascites carcinoma (EAC) cells growing in vivo was investigated by DNA flow cytometry. Different behavior patterns of EAC cells at the time after irradiation with low (2, 4, 6, 8 Gy) and high (10, 15, 20 Gy) doses were evaluated. While EAC cells showed a small progression delay in S phase and a dose-dependent block in G2/M phase after the irradiation with low doses, a clear additional block in G1/S phase was observed after irradiation with high doses. An assessment of the damage response and repair networks at the time after irradiation might have important implication for the development of cancer management and treatment. |
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