Blood kinetics of four intraperitoneally administered therapeutic candidate bacteriophages in healthy and neutropenic mice |
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| Authors: | Jumpei Uchiyama Yoshihiro Maeda Iyo Takemura Russ Chess-Williams Hiroshi Wakiguchi Shigenobu Matsuzaki |
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| Institution: | Departments of Pediatrics;, Microbiology and Infection, Faculty of Medicine, Kochi University, Oko-cho, Nankoku City, Kochi 783-8505, Japan;;and Faculty of Health Science &Medicine, Bond University, Robina, Queensland, Australia |
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| Abstract: | Due to multiple-drug resistant bacteria, phage therapy is being revisited. Although most animal experiments focus on therapeutic efficacy, the blood clearance kinetics of phages have not been well described. For further development of an efficient therapeutic strategy, information on phage blood kinetics is important. In this study, time-course concentration changes in peripheral blood of healthy and neutropenic mice were measured using four therapeutic phages (φMR11, KPP10, φEF24C, and KEP10). The results showed a two- to three-day rapid phage clearance, which fits a two-compartment model. |
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| Keywords: | bacteriophage blood kinetics phage therapy |
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