Characterization of the expression of the ALK receptor tyrosine kinase in mice |
| |
Authors: | Vernersson Emma Khoo Nelson K S Henriksson Maria L Roos Göran Palmer Ruth H Hallberg Bengt |
| |
Institution: | Department of Medical Biosciences/Pathology, Building 6M, 2nd Floor, Ume? University, S-901 87 Ume?, Sweden. |
| |
Abstract: | Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase, was first described as the fusion product causing a subtype of non-Hodgkin's lymphoma. To date Alk has been reported to be mainly expressed in CNS and other parts of the brain. Here we describe an extensive characterization of the mRNA and protein expression of ALK during mouse development. We show that mRNA and ALK protein show overlapping expressing patterns in specific regions of the central and the peripheral nervous systems. Furthermore, ALK is also expressed in the eye, nasal epithelium, olfactory nerve, tongue, skin, tissue surrounding the esophagus, stomach and midgut but not the hindgut. Expression of ALK is also found in testis and ovary. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|