The Effect of 3-Aminobenzamide on Thymidine Incorporation in Ultra-Violet Irradiated Chick Pigment Epithelium Cells |
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Authors: | ANNETTE BAICH PAUL E WANDA MICHAEL D MITCHELL |
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Abstract: | The addition of 3-aminobenzamide (3-AB) to cultures of chick embryo pigmented epithelium rescues these cells after high doses of ultraviolet treatment. The addition of 3-AB prevents cells from losing pre-formed protein and DNA and stimulates thymidine incorporation by the cells after ultraviolet irradiation. Since 3-AB is an inhibitor of poly (ADP) ribosylation, these observations support the conclusion that death of these cells after ultra-violet irradiation depends upon poly (ADP) ribosylation and may be an apoptotic response. |
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Keywords: | 3-Aminobenzamide Apoptosis Pigment epithelium cells Poly (ADP) ribosylation |
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