Hydrazinocurcumin,a novel synthetic curcumin derivative,is a potent inhibitor of endothelial cell proliferation |
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Authors: | Shim Joong Sup Kim Dong Hoon Jung Hye Jin Kim Jin Hee Lim Dongyeol Lee Seok-Ki Kim Kyu-Won Ahn Jong Woong Yoo Jong-Shin Rho Jung-Rae Shin Jongheon Kwon Ho Jeong |
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Affiliation: | Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, 98 Kunja-dong, Kwangjin-gu, 143-747, Seoul, South Korea |
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Abstract: | Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC(50)=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent. |
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