Production of interferons and change of the lymphocyte subpopulation phenotype in peripheral blood at cervical papillomavirus infection |
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| Authors: | Lazarenko L Spivak M Lakatosh V Kryvokhatska L Mikhailenko O Rudenko A Tkáciková L Mikula I |
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| Institution: | (1) Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kiev, Ukraine;(2) Bogomolets National Medical University, Health Ministry of Ukraine, Kiev, Ukraine;(3) Urology and Nephrology Institute, Academy of Medical Sciences, Kiev, Ukraine;(4) University of Veterinary Medicine, 041 81 Košice, Slovakia;(5) Neuroimmunology Institute, Slovak Academy of Sciences, Bratislava, Slovakia |
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| Abstract: | IFN-γ and IFN-α productionin vitro by peripheral blood cells activated by phytohemagglutinin or the Newcastle disease virus was impaired in patients with a
benign process, cervical intraepithelial neoplasm and cancerin situ associated with human papillomavirus infection. In case of IFN-γ and IFN-α production impairment following cervical papillomavirus
infection, the increased severity of disease was accompanied by remarkable IFN system suppression. The lower synthesis of
both IFN correlated with changes of some lymphocyte-subpopulation phenotype in peripheral blood. Lower CD4+ and CD3+ DR+ T cell concentrations were observed in papillomavirus-infected patients with impaired IFN production; impaired IFN-γ production
was accompanied by lower CD4/CD8 index. |
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