Secolignans with antiangiogenic activities from Peperomia dindygulensis |
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| Authors: | Lin Meng-Gan Yu De-Hong Wang Qi-Wei Lu Qin Zhu Wen-Jun Bai Fan Li Gui-Xiu Wang Xiang-Wen Yang Yi-Fang Qin Xue-Mei Fang Chao Chen Hong-Zhuan Yang Guo-Hong |
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| Institution: | 1. Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, P.?R. China (phone: +86‐21‐62479808;2. fax: +86‐21‐62473018);3. Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.?R. China (phone/fax: +86‐21‐64674721);4. Department of Pharmaceutical Sciences, School of Chemistry, Shanxi University, Taiyuan 030006, P.?R. China |
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| Abstract: | Two new secolignans, peperomins G and H ( 1 and 2 , resp.), were isolated from the whole plant of Peperomia dindygulensis, together with five known secolignans, peperomin A ( 3 ), peperomin E ( 4 ), peperomin B ( 5 ), 2,3‐trans‐2‐methyl‐3‐{(3‐hydroxy‐4,5‐dimethoxyphenyl)5‐methoxy‐3,4‐(methylenedioxy)phenyl]methyl}butyrolactone ( 6 ), 2,3‐cis‐2‐(hydroxymethyl)‐3‐{bis5‐methoxy‐3,4‐(methylenedioxy)phenyl]methyl}butyrolactone ( 7 ). Their structures and configurations were elucidated by spectroscopic methods including 2D‐NMR techniques. Antiangiogenic effects of all compounds were evaluated using human umbilical vein endothelial cells (HUVEC) proliferation and tube‐formation tests, with compounds 4 and 5 being active in the bioassay. Compounds 4 and 5 induced obvious cell toxicity to HUVEC with IC50 values of 1.64±0.19 and 8.44±0.4 μM , respectively. Compounds 4 and 5 also exhibited significant HUVEC tube formation‐inhibiting activity with IC50 values of 3.13±0.09 and 6.24±0.12 μM , respectively. |
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| Keywords: | Peperomia dindygulensis Peperomins G and H Secolignans Antiangiogenic activity |
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