Three new cytochalasins from the marine-derived fungus Spicaria elegans KLA03 by supplementing the cultures with L- and D-tryptophan |
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| Authors: | Wang Fa-Zuo Wei Hong-Juan Zhu Tian-Jiao Li De-Hai Lin Zhen-Jian Gu Qian-Qun |
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| Affiliation: | 1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P.?R. China, (phone: +86‐532‐82032065;2. fax: +86‐532‐82033054) |
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| Abstract: | Three new cytochalasins Z21–Z23 ( 1 – 3 , resp.), together with five analogs, 4 – 8 , were isolated from Spicaria elegans KLA03 by the OSMAC (one strain‐many compounds) approach with adding L ‐ and D ‐tryptophan during its cultivation. The structures of new cytochalasins were elucidated on the basis of comprehensive 1D‐ and 2D‐NMR and HR‐ESI‐MS analyses. Cytochalasins Z21 and Z22 ( 1 and 2 , resp.), and compound 5 showed cytotoxic activities against A‐549 cell lines with IC50 values of 8.2, 20.0, and 3.1 μM , respectively. |
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| Keywords: | Spicaria elegans Cytochalasins Z21 – Z23 Fungi Marine fungi Cytotoxic activity |
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