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Spantide: failure to antagonize bombesin-induced stimulation of gastrin secretion in dogs
Authors:T Pappas  D Hamel  H Debas  J Walsh  Y Tache
Institution:Center for Ulcer Research and Education, VA Wadsworth Medical Center, Los Angeles, CA 90073 USA
Abstract:Spantide (d-Arg1, d-Trp7,9, Leu11] substance P) was shown to function not only as a substance P receptor antagonist but also as a bombesin receptor antagonist. This study examined the effects of spantide on intravenous bombesin-induced stimulation of gastrin and acid secretion. Dogs were infused with spantide (1 or 10 nmol kg 1 hr 1) or saline and bombesin (60 pmol kg-1 hr-1), and the gastric acid and plasma gastrin responses were monitored. Spantide did not significantly modify gastrin or gastric acid secretion induced by bombesin. It is concluded that spantide may not be a useful bombesin antagonist for in vivo studies.
Keywords:Bombesin  Spantide  Gastrin  Gastric acid  Dogs
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