Dissecting the genetic effect of the CRH system on anxiety and stress-related behaviour |
| |
Authors: | Deussing Jan M Wurst Wolfgang |
| |
Affiliation: | Max-Planck-Institute of Psychiatry, Molecular Neurogenetics, Kraepelinstrasse 2-10, 80804 Munich, Germany. |
| |
Abstract: | Corticotropin-releasing hormone (CRH) plays a central role in the adaptation of the body to stress. CRH integrates the endocrine, autonomic and behavioural responses to stress acting as a secretagogue within the line of the hypothalamic pituitary adrenocortical (HPA) system and as a neurotransmitter modulating synaptic transmission in the central nervous system. Accumulating evidence suggests that the neuroendocrine and behavioural symptoms observed in patients suffering from major depression are at least in part linked to a hyperactivity of the CRH system. Genetic modifications of the CRH system by conventional and conditional gene targeting strategies in the mouse allowed us to study the endogenous mechanisms underlying HPA system regulation and CRH-related neuronal circuitries involved in pathways mediating anxiety and stress-related behaviour. |
| |
Keywords: | Anxiety Stress Genetic factors Corticotropin-releasing hormone HPA system Mouse Anxiété Stress Facteurs génétiques Corticolibérine Système HPA Souris |
本文献已被 ScienceDirect PubMed 等数据库收录! |