RHO SIGNALING in vascular diseases |
| |
Authors: | Seasholtz Tammy M Brown Joan Heller |
| |
Institution: | Department of Pharmacology, University of California at San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0636, USA. |
| |
Abstract: | Rho signaling pathways in vascular smooth muscle cells are highly activated in hypertension, a condition associated with a variety of vascular diseases, including restenosis injury and atherosclerosis. In this review we suggest that inflammatory cytokines and agonists of G protein-coupled receptors that activate Rho are effective triggers of vascular disease. Accordingly, Rho kinase inhibitors and statins may have therapeutic potential for preventing vascular disease characterized by Rho-mediated cell proliferation and gene expression. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|