Outside and in: development of neuronal excitability |
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Authors: | Spitzer Nicholas C Kingston Paul A Manning Timothy J Conklin Matthew W |
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Affiliation: | Neurobiology Section 0357, Biology Division, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0357, USA. |
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Abstract: | Investigation of the development of excitability has revealed that cells are often specialized at early stages to generate Ca(2+) transients. Studies of excitability have converged on the central role of Ca(2+) and K(+) channels in the plasmalemma that regulate Ca(2+) influx and have identified critical functions for receptor-activated channels in the endoplasmic reticulum that allow efflux of Ca(2+) from intracellular stores. The parallels between excitability in these two locations motivate future work, because comparison of their properties identifies shared attributes. |
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