Glutamatergic neurotransmission in the synapsin I and II double knock-out mouse |
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Authors: | Bogen Inger Lise Jensen Vidar Hvalby Øivind Walaas S Ivar |
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Institution: | aDepartment of Biochemistry, Institute of Basic Medical Science, University of Oslo, N-0316 Blindern, Oslo, Norway;bDepartment of Physiology, Institute of Basic Medical Science, University of Oslo, N-0316 Blindern, Oslo, Norway |
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Abstract: | The synaptic vesicle-associated synapsin proteins may participate in synaptic transmission, but their exact functional role(s) here remain(s) uncertain. We here briefly describe the important characteristics of the synapsin proteins, and review recent studies on transgenic mice devoid of the gene products encoded by the synapsin I and II genes, where both neurochemical, cell biological and electrophysiological methods have been employed. We present evidence for synapsin effects on both neurotransmitter synthesis and homeostasis, as well as on synaptic vesicle development and functions. Moreover, we describe physiological analyses of excitatory glutamatergic hippocampal synapses where a novel synapsin-dependent delayed response enhancement (DRE) phase occurs, and demonstrate the postnatal developmental patterns of both frequency facilitations and DRE responses. Finally, we report synapsin I and II effects in distinct excitatory glutamatergic synapses in the hippocampus, and indicate that synapsin-dependent modulations of synaptic function may use distinct presynaptic response patterns in order to induce different classes of presynaptic plasticity. |
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Keywords: | Abbreviations: DKO synapsin I and II double knock out mice TKO synapsin I II and III triple knock out mice DRE delayed response enhancement RRP readily releasable vesicle pool RP reserve vesicle pool SV synaptic vesicles CaMK calcium&ndash calmodulin dependent protein kinase PKA cyclic AMP-dependent protein kinase VGLUT vesicular glutamate transporter GABA 4-aminobutyrate VGAT vesicular GABA and glycine transporter VMAT vesicular monoamine transporter VAChT vesicular ACh transporter WT wild type mice ACh acetylcholine |
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