The fibroblast growth factor family: Structural and biological properties |
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| Institution: | 1. Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea;2. Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea;3. Department of Neurology, Changwon Hospital, Gyeongsang National University, Changwon, Republic of Korea;4. Department of Neurology, Korea University Guro Hospital, Seoul, Republic of Korea;1. Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN;2. Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN;3. Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN;4. Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN;5. Applied Science, Premier, Inc, Charlotte, NC;6. Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN;2. Department of Neurology, Faculty of Medicine, Mansoura University, Mansoura, Egypt;1. Department of Clinical Neurosciences, Institute of Medical Biosciences, Tokushima University, Tokushima, Japan;2. Department of Neurosurgery, Institute of Medical Biosciences, Tokushima University, Tokushima, Japan;3. Department of Radiology, Institute of Medical Biosciences, Tokushima University, Tokushima, Japan |
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| Abstract: | This article sumarizes the structural and biological properties of the family of fibroblast growth factors (FGF). Basic FGF (bFGF) and acidic FGF (aFGF) are the best characterized members of this family. bFGF and aFGF are potent modulators of cell proliferation, motility and differentiation. They are also potent angiogenesis factors in vivo. Some of the important biological characteristics of bFGF and aFGF discussed in the review include the affinity of bFGF and aFGF for heparin, their lack of secretion in culture and their association with extracellular matrix. Recently, several oncogenes, 40–50% homologous in sequence to bFGF and aFGF have been identified. These include int-2, hst, K-fgf and FGF-5. The structural and biological properties of these FGF-related oncogenes are also discussed. |
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