Two-dimensional crystalline arrays of Na,K-ATPase with new subunit interactions induced by cobalt-tetrammine-ATP |
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| Institution: | 1. Laboratório de Ciências Químicas, Universidade Estadual do Norte Fluminense, Campos dos Goytacazes/RJ, 28013-602, Brazil;2. P&D NanoBusiness Informação e Inovação, Duque de Caxias/RJ, 25250-020, Brazil;3. Laboratório de Biologia Celular e Tecidual, Universidade Estadual do Norte Fluminense, Campos dos Goytacazes/RJ, 28013-602, Brazil |
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| Abstract: | Purified membrane-bound Na,K-ATPase incubated with cobalt-tetrammine-ATP Co(NH3)4ATP], which is a stable MgATP complex analog, shows two new types of membrane crystals, a new p21 form and a p4 form. The building blocks of the crystalline arrays correspond to (αβ)2 dimers of the enzyme protein suggesting that α-α interaction may be important in the pumping process. |
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