Early Deсline in Rat Soleus Passive Tension with Hindlimb Unloading: Inactivation of Cross-bridges or Activation of Calpains? |
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| Authors: | I O Petrova S A Tyganov T M Mirzoev A K Tsaturyan I B Kozlovskaya B S Shenkman |
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| Institution: | 1.Institute of Biomedical Problems,Russian Academy of Sciences,Moscow,Russia;2.Institute of Mechanics,Moscow State University,Moscow,Russia |
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| Abstract: | The study was aimed at testing the hypotheses about the role of cross-bridges and calpains in reduction of rat soleus passive tension under conditions of hindlimb unloading. For this purpose, we used an inhibitor of μ-calpain PD 150606 as well as a blocker of actomyosin interaction (blebbistatin). It was found for the first time that a decrease in passive tension of rat soleus after 3-day hindlimb unloading is associated with the activity of μ-calpain and does not depend on the processes of cross-bridges formation. |
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