Phospholipase A2 Inhibitors Modulate the Effect of Trifluoperazine on the Intracellular Ca2+ Concentration in Macrophages |
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| Authors: | Z. I. Krutetskaya L. S. Milenina A. A. Naumova S. N. Butov V. G. Antonov A. D. Nozdrachev |
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| Affiliation: | 1.St. Petersburg State University,St. Petersburg,Russia |
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| Abstract: | Using Fura-2AM microfluorimetry, it was shown for the first time that phospholipase A2 inhibitors 4-bromophenacyl bromide and glucocorticosteroids prednisolone and dexamethasone attenuate Ca2+ responses induced by neuroleptic trifluoperazine in macrophages. The results suggest the involvement of phospholipase A2 and arachidonic acid metabolism cascade in the effect of trifluoperazine on intracellular Ca2+ concentration in macrophages. |
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