Physicochemical Properties and Anti-Opisthorchosis Effect of Mechanochemically Synthesized Solid Compositions of Praziquantel with Glycyrrhizic Acid Disodium Salt |
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| Authors: | E S Meteleva Yu S Chistyachenko L P Suntsova M A Tsyganov G B Vishnivetskaya D F Avgustinovich M V Khvostov N E Polyakov T G Tolstikova V A Mordvinov A V Dushkin N Z Lyakhov |
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| Institution: | 1.Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch,Russian Academy of Sciences,Novosibirsk,Russia;2.Institute of Cytology and Genetics, Siberian Branch,Russian Academy of Sciences,Novosibirsk,Russia;3.Vorozhtsov Institute of Organic Chemistry, Siberian Branch,Russian Academy of Sciences,Novosibirsk,Russia;4.Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch,Russian Academy of Sciences,Novosibirsk,Russia;5.Novosibirsk State University,Novosibirsk,Russia |
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| Abstract: | The mechanochemical preparation of solid compositions of praziquantel with plant saponin (glycyrrhizic acid disodium salt) is described. The study of a number of physicochemical parameters showed that dissolving solid compositions in water is accompanied by the inclusion of praziquantel molecules into micelles, which are formed in the solution of the glycyrrhizic acid disodium salt. Using the opisthorchiasis model caused by Opisthorchis felineus, we found a 4- to 11-fold increase in the anthelmintic activity of praziquantel in the composition as compared to the official praziquantel. According to the pharmacokinetic data, the use of the composition increased the bioavailability of praziquantel 3 times. |
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