Glucosiduronidation and esterification of androsterone by human breast tumors |
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Authors: | Uma Raju Susan Kfcdner Mortimer Levitz Alexander Kaganowicz Ancel Blaustein |
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Institution: | Department of Obstetrics and Gynecology New York University School of Medicine New York, New York 10016 USA;Department of Pathology Booth Memorial Medical Center Flushing, New York 11355 USA |
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Abstract: | The metabolism of 3H-androsterone was studied in homogenates (fortified with uridine 5'-diphosphoglucuronic acid and andenosine 3'-phosphate 5'-phosphosulfate) of eighteen breast tumors, one muscle underlying the primary breast carcinoma and metastatic axillary lymph nodes from a patient with suspected primary breast cancer. The major metabolites identified were less polar than androsterone. On saponification these lipoidal derivatives afforded androsterone as the only product (3 to 48%). Unmetabolized androsterone and lesser quantities of epiandrosterone, 5α-androstane-3α,17β-diol and 5α-androstane-3,17-dione comprised the free steroid fraction. Androsterone glucosiduronate was isolated (0.17–4.1%) from eight breast tumor homogenates and from the node tissue incubation (17%). There was no apparent correlation between glucuronyltransferase activity and histopathology or estrogen receptor content. |
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