Plant telomere-binding proteins |
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Authors: | M Kuchar |
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Institution: | (1) Department of Functional Genomics and Proteomics, Masaryk University Brno, Kotlarska 2, CZ-60200 Brno, Czech Republic |
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Abstract: | Telomere-binding proteins have recently been recognised not only as necessary building blocks of telomere structure, but namely
as components which are of central importance to telomere metabolism being involved in regulation of telomere length as well
as in protective (capping) function of telomeres. Although the knowledge on plant telomeric DNA-binding proteins lags behind
that in human and yeast, recent data show both analogies and plant-specific features in the composition and interactions of
telomeric proteins. This review focuses primarily on proteins with known amino acid sequence. These can be classified into
following groups: 1) the family of proteins with Myb domain at C-terminus, 2) proteins with Myb domain at N-terminus, both binding double-stranded DNA of telomeric repeats TTTAGGG, 3) the single-stranded DNA-binding proteins, and 4) other proteins that act also in non-telomeric chromatin regions. Proteins with C-terminal Myb domain reported as IBP family
were previously found in human, whereas Smh family representing proteins with Myb domain at N-terminus was identified only
in plants. Also RRM family of the single-stranded DNA-binding proteins is likely to be plant specific. |
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Keywords: | telomere-associated proteins DNA-binding Arabidopsis thaliana |
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