Inducer Expulsion Is Not a Determinant of Diauxic Growth in Streptococcus bovis |
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Authors: | Daniel B Kearns Gregory M Cook James B Russell |
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Institution: | (1) Section of Microbiology, Cornell University, Wing Hall, Ithaca, NY 14853, USA , US;(2) Agricultural Research Service, USDA, Ithaca, NY 14853, USA , US |
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Abstract: | When Streptococcus bovis JB1 was repeatedly transferred in a medium that contained the non-metabolizable glucose analog, 2-deoxyglucose, it lost its
phosphotransferase system (PTS) for glucose but was still able to take up glucose via a facilitated diffusion mechanism. The
wild type (JB1) had an inducible enzyme II lactose, but the mutant (JB12DG) had a constitutive lactose PTS. JB12DG was no longer able to exclude lactose when it was provided with glucose, but it retained its ability to expel a non-metabolizable
lactose analog. Because JB12DG could utilize glucose and lactose simultaneously and grow in a non-diauxic fashion, it appeared that inducer expulsion was
not an important catabolite regulatory mechanism. Based on these results, inducer expulsion may be an artifact of non-metabolizable
sugars. |
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Keywords: | |
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