| Pax7基因在C 2C12细胞内的表达及诱导失活(简报) |
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| 引用本文： | 夏顺汉,姚鑫,Ahmed MANSOURI,Peter GRUSS.Pax7基因在C 2C12细胞内的表达及诱导失活(简报)[J].分子细胞生物学报,1996(2). |
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| 作者姓名： | 夏顺汉 姚鑫 Ahmed MANSOURI Peter GRUSS |
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| 作者单位： | 中科院上海细胞生物学研究所，中科院上海细胞生物学研究所，Max-Planck Institute of Biophysical Chemistry，37077 Gottingen，Germany，Max-Planck Institute of Biophysical Chemistry，37077 Gottingen，Germany 上海 200031，上海 200031 |
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| 基金项目： | 欧共体Fellowship资助项目 |
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| 摘 要： | 配对框(Paired box)首先是在果蝇的分节基因中发现的一段DNA保守序列,编码能与DNA特异结合的一个蛋白质结构域。这些序列在进化中有一定的保守性,在许多种生物基因组内存在,其中包括小鼠和人。至今为止,在小鼠中分离到九个含配对框的Pax基因,按基因发现时序,分别定名为Pax 1至Pax 9。Pax 7是其中的一个成员,它不但含有配对框,还含有八肽结构(Octapeptide)和
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| 关 键 词： | 配对框 成肌作用 细胞分化 |
THE EXPRESSION OF PAX 7 IN C2C12 CELL LINE AND ITS INDUCIBLE INACTIVATION |
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| XIA Shun Han Yao Zhen Ahmed MANSOURI Peter GRUSS.THE EXPRESSION OF PAX 7 IN C2C12 CELL LINE AND ITS INDUCIBLE INACTIVATION[J].Journal of Molecular Cell Biology,1996(2). |
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| Authors: | XIA Shun Han Yao Zhen Ahmed MANSOURI Peter GRUSS |
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| Institution: | XIA Shun Han Yao Zhen Ahmed MANSOURI* Peter GRUSS* |
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| Abstract: | Pax 7 is a member of mouse Pax gene family. It was expressed from day 8 to 17 p. c. during murine embryogenesis, mainly restricted to the central nerve systems. Additional Pax 7 expression could be followed during myogenesis from the derma-myotome of the somites to the skeletal muscle tissues. For the first time, we demonstrated that Pax 7 is expressed in mouse myoblast cell line, C 2 C 12. The exp-
ression of Pax 7 was blocked when C 2 C12 cells were induced to differentiate into myotube. Moreover, cells of mesodermal origin, in particular of the mouse embryo fibroblast cell line C3H10T1/2 which were especially permissive to the action of myogenic HLH proteins, did not express Pax 7. These results suggest that Pax 7 may be a suppressive factor for the myoblast differentiation of C 2 C 12 cells in vitro. |
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| Keywords: | Paired-box myogenesis cell differentiaion |
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