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Change in alpha-ketoglutarate dehydrogenase cooperative properties due to dihydrolipoate and NADH |
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| Authors: | V I Bunik O A Buneeva V S Gomazkova |
| Affiliation: | Department of Biochemistry, Moscow State University, USSR. |
| Abstract: | Reducing 2 SH-groups of KGD by dihydrolipoate leads to cooperativity in substrate binding. Cooperative properties of KGD in the KGD complex are modulated by NADH. Physiological significance of these observations is discussed. |
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