A potassium conductance activated by hyperpolarization in paramecium |
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| Authors: | Donata Oertel Stanley J Schein Ching Kung |
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| Institution: | (1) Present address: Laboratory of Molecular Biology and Department of Genetics, University of Wisconsin, 53706 Madison, Wisconsin;(2) Albert Einstein College of Medicine, 10461 Bronx, N.Y.;(3) Present address: Department of Neurobiology, Harvard Medical School, 25 Shattuck St., 02115 Boston, MA;(4) Present address: Department of Psychology Department of Genetics, M.I.T., 02139 Cambridge, MA |
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| Abstract: | Summary Voltage clamp studies show that the wild-type membrane ofParamecium tetraurelia contains a conductance component which is sensitive to hyperpolarization. This component manifests itself as  anomalous , or inward going, rectification of membrane voltage in response to applied constant current pulses and as a hyperpolarizing spike when no K is added to the external solution (Y. Satow, C. Kung, 1977.J. Comp. Physiol.
119 99). Like the conductances which underlie anomalous rectification in other cells, the hyperpolarization-sensitive conductance inParamecium is specific for K, and the magnitude of the voltage-dependent conductance change depends not only on voltage but also on external potassium concentration. The internal potassium ion concentration ofParamecium is calculated to be between 17 and 18mm. |
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