Alpha-1-antitrypsin types in five Chinese national minorities |
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| Authors: | Ying Qi-long Zhang Mei-lin Liang Chih-chuan Chen Li-chang Chen Luo-fu Huang You-wen Wang Rong-xin Zhang Ni-jia Li Hou-jun Liu Shi-shan Gao Er-xi |
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| Affiliation: | (1) Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China;(2) Department of Biochemistry, Hainan University School of Medicine, Guangdong, China;(3) Department of medicine, 303 PLA Hospital, Guangxi, China;(4) Department of Human Genetics, PLA General Hospital of Urumgi, Xinjiang, China;(5) Clinical Laboratory, 253 PLA Hospital, Inner Mongolia, China |
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| Abstract: | Summary The frequencies of alpha-1-antitrypsin alleles were determined for five Chinese national minorities: Uigur, Korean, Mongolian, Chuang, and Li. PI*S and PI*Z alleles are not found in the five populations studied. PI*ETOK allele is present in Korean, Mongolian, and Chuang populations, and Etokyo is a very common alpha-1-antitrypsin variant in Chinese. Other alleles which occur in more than one of the minorities are PI*X (Mongolian and Chuang) and PI*M4 (Korean and Uigur). The high frequency of PI*M4 in the Uigur population suggests a probably Occidental origin of this nationality. |
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