Enzymatic synthesis of beta-lactam antibiotics and N-fatty-acylated amino compounds by the acyl-transfer reaction catalyzed by penicillin V acylase from Streptomyces mobaraensis |
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Authors: | Koreishi Mayuko Tani Kazuha Ise Yuuichi Imanaka Hiroyuki Imamura Koreyoshi Nakanishi Kazuhiro |
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Affiliation: | Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, Japan. |
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Abstract: | Penicillin V acylase from Streptomyces mobaraensis (Sm-PVA) showed high acyl-transfer activity in reactions using methyl esters of carboxylic acid (acyl donor) and amino compounds (nucleophile), to produce the corresponding amides. Moreover, Sm-PVA had broad substrate specificity, as indicated by the fact that it catalyzed the efficient synthesis of beta-lactam antibiotics, capsaicin derivatives, and N-fatty-acyl-amino acid/N-fatty-acyl-peptide derivatives. |
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